I used to live there, so when I visit family we always hit the breweries. I go like once a year now.
Like everyone has said, Rhinegeist and Mad Tree are the big ones... As tall as the Rhinegeist brewery is, Mad tree is long.... Both have a ton of offerings and are above average to say the least. Mad Tree has a third party renting space in that enormous tasting room and that third party does wood fire pizzas. Stellar.
Hands down... best beer in my opinion is Listermanns. It looks like a dive but -gawd damn. Big thick juicy neipas, chewy stouts.... and everything in between. I can not wait to go back. They have consistently placed in the Festival of the Barrel Aged Beers here in Chicago.
The Taft Ale house on Race Street is a converted church and is absolutely beautiful inside. Food is great... it is a perfect place to start for lunch.
Have a great trip! Don't forget the Skyline Chilli and Graters Ice Cream!
Go Bengals! WHO DEY!!